Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model

Acta Cir Bras. 2014;29 Suppl 1:39-44. doi: 10.1590/s0102-86502014001300008.


Purpose: To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats.

Methods: Thirty-eight male Wistar rats were divided into 4 groups: normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty acids (HF-P), and high-fat diet rich in saturated and polyunsaturated fatty acids (HF-SP). Blood samples were collected and the penises were removed for histomorphometrical and immunohistochemical analysis.

Results: All high-fat diets promoted an increase in the body mass (p<0.0001). The HF-S and HF-SP groups presented hyperglycemia (p=0.0060), hyperinsulinemia (p=0.0030), and hypercholesterolemia (p=0.0020). Concerning the penis, the high-fat diets led to an increase in the collagen fibers (p<0.0001) and smooth muscle cell density area (p=0.0027), and a decline in the sinusoidal space density area (p<0.0001) and corpus cavernosum cell proliferation (p=0.0003).

Conclusion: Diets rich in saturated and/or polyunsaturated fatty acids promoted overweight and induced penile changes in rodent models, which may lead to the development of erectile dysfunction.

MeSH terms

  • Actins / analysis
  • Animals
  • Collagen / analysis
  • Diet, High-Fat / adverse effects*
  • Dietary Fats / adverse effects*
  • Dietary Fats / metabolism
  • Erectile Dysfunction / etiology*
  • Fatty Acids, Monounsaturated / adverse effects*
  • Fatty Acids, Monounsaturated / metabolism
  • Male
  • Models, Animal
  • Myocytes, Smooth Muscle / metabolism
  • Overweight / metabolism
  • Penis / pathology*
  • Proliferating Cell Nuclear Antigen / analysis
  • Random Allocation
  • Rapeseed Oil
  • Rats, Wistar
  • Risk Factors


  • Actins
  • Dietary Fats
  • Fatty Acids, Monounsaturated
  • Proliferating Cell Nuclear Antigen
  • Rapeseed Oil
  • smooth muscle actin, rat
  • Collagen
  • lard