Acantholytic Acanthoma of the Eyelid: Unusual Presentation

Ophthalmic Plast Reconstr Surg. 2016 Jul-Aug;32(4):e94-5. doi: 10.1097/IOP.0000000000000276.


Acantholytic acanthoma is a benign epidermal tumor with a truncal predisposition and is not previously reported as an eyelid mass. A 63-year-old man, presented with a history of nodular masses of both his eyelid margin and eyelid surface of 3 years duration. Excision biopsy of lesion of eyelid margin was consistent with dermal nevus. Lesions of the eyelid surface displayed prominent acanthosis, acantholysis, and spongiosis. Variable hyperkeratosis and papillomatosis was also noted. There was absence of cytological atypia or mitoses. The microscopic picture was consistent with acantholytic acanthoma. The presence of extensive acantholysis in the present case excluded incidental focal epidermolytic hyperkeratosis and focal acantholytic dyskeratosis. Acantholytic vesiculobullous disorders and numerous acanthotic disorders, which are more common in the eyelid, need exclusion. To the authors' best knowledge, as acantholytic acanthoma of the eyelid is not previously reported, they recommend that it should be included as differential diagnoses of benign epidermal lesions of eyelid.

Publication types

  • Case Reports

MeSH terms

  • Acantholysis / diagnosis*
  • Acanthoma / diagnosis*
  • Biopsy
  • Diagnosis, Differential
  • Eyelid Neoplasms / diagnosis*
  • Eyelids / diagnostic imaging*
  • Humans
  • Male
  • Middle Aged