Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians

Diabetes. 2015 Jan;64(1):291-8. doi: 10.2337/db14-0563. Epub 2014 Sep 3.

Abstract

Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Adult
  • Aged
  • Asian Continental Ancestry Group / genetics*
  • Blood Glucose / genetics*
  • Blood Glucose / metabolism*
  • Cytoskeletal Proteins
  • Far East
  • Fasting
  • Female
  • Genetic Variation
  • Genome-Wide Association Study*
  • Genotype
  • Guanine Nucleotide Exchange Factors / genetics
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Protein-Serine-Threonine Kinases / genetics
  • Pyruvate Dehydrogenase Acetyl-Transferring Kinase
  • Receptor, IGF Type 1 / genetics
  • Tumor Suppressor Proteins / genetics

Substances

  • Adaptor Proteins, Signal Transducing
  • Blood Glucose
  • Cytoskeletal Proteins
  • Guanine Nucleotide Exchange Factors
  • KANK1 protein, human
  • PDK1 protein, human
  • Pyruvate Dehydrogenase Acetyl-Transferring Kinase
  • RAPGEF4 protein, human
  • Tumor Suppressor Proteins
  • Receptor, IGF Type 1
  • Protein-Serine-Threonine Kinases