Does anything work for anaemia in myelofibrosis?

Best Pract Res Clin Haematol. 2014 Jun;27(2):175-85. doi: 10.1016/j.beha.2014.07.011. Epub 2014 Jul 18.

Abstract

Anaemia is a common finding at diagnosis in myelofibrosis, and becomes a symptomatic problem in most patients with time. There are several treatment options for specific anaemia treatment, none of which has been tested in large, randomized, controlled trials. However, as myelofibrosis is not a disease with spontaneous remissions, even non-randomized trials carry weight. In this survey, the existing evidence will be analysed, both for the commonly used treatments like erythropoiesis-stimulating agents, androgens and thalidomide and for the new drugs in the area, and conclusions will be drawn concerning standard clinical anaemia treatment in myelofibrosis, which according to evidence from studies has a 40-50% chance of response in patients with not too advanced disease.

Keywords: anaemia; anaemia treatment; myelofibrosis; myeloproliferative neoplasm.

Publication types

  • Review

MeSH terms

  • Androgens / therapeutic use*
  • Anemia / complications
  • Anemia / drug therapy*
  • Anemia / pathology
  • Blood Transfusion
  • Erythropoietin / therapeutic use
  • Hematinics / therapeutic use*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Interferons / therapeutic use
  • Lenalidomide
  • Oxymetholone / therapeutic use
  • Primary Myelofibrosis / complications
  • Primary Myelofibrosis / drug therapy*
  • Primary Myelofibrosis / pathology
  • Protein Kinase Inhibitors / therapeutic use
  • Pyrazoles / therapeutic use
  • Thalidomide / analogs & derivatives
  • Thalidomide / therapeutic use*

Substances

  • Androgens
  • EPO protein, human
  • Hematinics
  • INCB018424
  • Immunosuppressive Agents
  • Protein Kinase Inhibitors
  • Pyrazoles
  • Erythropoietin
  • Thalidomide
  • Interferons
  • pomalidomide
  • Lenalidomide
  • Oxymetholone