Strategies to improve drug development for sepsis

Nat Rev Drug Discov. 2014 Oct;13(10):741-58. doi: 10.1038/nrd4368. Epub 2014 Sep 5.


Sepsis, a common and potentially fatal systemic illness, is triggered by microbial infection and often leads to impaired function of the lungs, kidneys or other vital organs. Since the early 1980s, a large number of therapeutic agents for the treatment of sepsis have been evaluated in randomized controlled clinical trials. With few exceptions, the results from these trials have been disappointing, and no specific therapeutic agent is currently approved for the treatment of sepsis. To improve upon this dismal record, investigators will need to identify more suitable therapeutic targets, improve their approaches for selecting candidate compounds for clinical development and adopt better designs for clinical trials.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Drug Design*
  • Humans
  • Molecular Targeted Therapy
  • Randomized Controlled Trials as Topic
  • Research Design
  • Sepsis / drug therapy*
  • Sepsis / microbiology