Objective: To establish the cerebrovascular disease risks in the Chornobyl clean-up workers with regard to whole-body external dose and non-radiation factors i.e. biological, social-and-hygienic, behavioral ones.
Materials and methods: Risk-analysis was based on the cohort of the Chornobyl male clean-up workers of 1986-1987 period (8625 men including 3623 with known whole-body external radiation dose values). Data from the Clinical-and-epidemiological registry, National Research Centre for Radiation Medicine were used. Observation period was since 1992 till 2010. We have used the approach with the internal control group with radiation doses less than 0.05 or 0.1 Gy.
Results: The statistically significant radiation risks were established for the chronic forms of cerebrovascular disease at doses 0.5 Gy and higher, for some forms of the disease in certain dose-age strata i.e. 0.25 Gy and more. Statistically significant non-radiation risks for cerebrovascular disease were recorded with regard to age, psychoemotional stress, alcohol abuse, malnutrition, smoking, harmful working conditions etc. Role of age as a confounding factor was analyzed under the assessing of radiation risks with Mantel-Haenszel method application to improve the estimates of radiation effects.
Cel'. Opredelenie riskov razvitija cerebrovaskuljarnoj patologii sredi uchastnikov likvidacii avarii na ChAJeS (ULPA) s uchetom dozy vneshnego obluchenija vsego tela, a takzhe neradiacionnyh faktorov (biologicheskih, social'no-gigienicheskih, povedencheskih) Materialy i metody. Po dannym kliniko-jepidemiologicheskogo registra NNCRM proveden risk-analiz na kogorte ULPA 1986–1987 gg. muzhskogo pola (8625 chelovek, v t.ch. 3623 chelovek s dozami vneshnego obluchenija vsego tela). Period nabljudenija 1992–2010 gg. Ispol'zovalas' vnutrennjaja kontrol'naja gruppa s dozami men'she 0,05 Gr ili 0,1 Gr. Rezul'taty. Ustanovleny statisticheski dostovernye radiacionnye riski razvitija hronicheskih form cerebrovaskuljarnoj patologii pri dozah ot 0,5 Gr, dlja otdel'nyh form cerebrovaskuljarnoj patologii v nekotoryh dozo-vozrastnyh stratah – ot 0,25 Gr. Zafiksirovany statisticheski dostovernye neradiacionnye riski razvitija cerebrovaskuljarnyh boleznej s uchetom vozrasta, psihojemocional'nogo perenaprjazhenija, zloupotreblenija alkogolem, narushenij v pitanii, kurenija, neblagoprijatnyh uslovij truda i dr. Pri ocenke radiacionnyh riskov proanalizirovana rol' vozrasta kak faktora smeshivanija; s ispol'zovaniem metoda Mantel-Hanzela vneseny opredelennye utochnenija v ocenki radiacionnyh jeffektov.
Keywords: Chornobyl accident; Chornobyl clean-up workers; cerebrovascular disease; radiation and non-radiation factors; registries; risk.
Krasnykova L. Y., Buzunov V. A., Solonovych S. Y., 2013.