TNF-α-308G/A polymorphism contributes to obstructive sleep apnea syndrome risk: evidence based on 10 case-control studies

Yanping Wu; Chao Cao; Yinfang Wu; Chao Zhang; Chen Zhu; Songmin Ying; Zhihua Chen; Huahao Shen; Wen Li

doi:10.1371/journal.pone.0106183

TNF-α-308G/A polymorphism contributes to obstructive sleep apnea syndrome risk: evidence based on 10 case-control studies

PLoS One. 2014 Sep 5;9(9):e106183. doi: 10.1371/journal.pone.0106183. eCollection 2014.

Authors

Yanping Wu¹, Chao Cao², Yinfang Wu¹, Chao Zhang¹, Chen Zhu¹, Songmin Ying¹, Zhihua Chen¹, Huahao Shen¹, Wen Li¹

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
² Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Department of Respiratory Medicine, Affiliated Hospital of School of Medicine, Ningbo University, Ningbo, China.

Abstract

Objective: The aim of our study was to investigate the association between the TNF-α-308G/A polymorphism and obstructive sleep apnea syndrome (OSAS).

Method: The Medline, Web of Science, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Cochrane Central Register of Controlled Trials were searched. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to study TNF-α-308G/A polymorphism and risk of OSAS.

Result: 10 case-control studies were included in our meta-analysis. The results from our study showed that the TNF-α-308G/A polymorphism was significantly associated with risk of OSAS (A vs. G: OR = 1.67, 95% CI = 1.43-1.95). In the subgroup analysis by ethnicity, the statistical similar results were observed both in European (A vs. G: OR = 1.68, 95% CI = 1.35-2.08) and Asian population (A vs. G: OR = 2.02, 95% CI = 1.50-2.71). When stratified by age, a significantly increased risk was observed in adult carries A allele compared with G allele (OR = 1.79, 95% CI = 1.50-2.13), whereas no association was found in children (OR = 1.09, 95% CI = 0.70-1.69).

Conclusion: Our study suggested that the TNF-α- 308G/A polymorphism contributed to the susceptibility to the risk of OSAS. Additional well-designed large studies are needed to validate our findings.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Case-Control Studies
Genetic Predisposition to Disease*
Humans
Odds Ratio
Polymorphism, Single Nucleotide*
Publication Bias
Sleep Apnea, Obstructive / genetics*
Tumor Necrosis Factor-alpha / genetics*

Substances

Tumor Necrosis Factor-alpha

Grants and funding

This work was supported by grant of National Natural Science Foundation of China (No. 81170037 and No. 81370126) and Natural Science Foundation of Ningbo (No. 2012A610257). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.