New pROSpects for PTP1B: micro-managing oncogene-induced senescence

Mol Cell. 2014 Sep 4;55(5):651-3. doi: 10.1016/j.molcel.2014.08.015.


Oncogene-induced senescence (OIS) provides an important, but incompletely understood, barrier to tumorigenesis. In this issue, Yang et al. (2014) surprisingly report that inactivation of PTP1B by reactive oxygen species is essential for OIS, via effects on AGO2 and microRNA maturation.

Publication types

  • Comment

MeSH terms

  • Argonaute Proteins / metabolism*
  • Gene Silencing*
  • Humans
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / physiology*
  • Tyrosine / metabolism*
  • ras Proteins / physiology*


  • AGO2 protein, human
  • Argonaute Proteins
  • Tyrosine
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • ras Proteins