Hereditary Spastic Paraplegia: Clinical Principles and Genetic Advances

Semin Neurol. 2014 Jul;34(3):293-305. doi: 10.1055/s-0034-1386767. Epub 2014 Sep 5.

Abstract

Hereditary spastic paraplegia (HSP) refers to inherited disorders in which spastic gait is either the only feature or is a major syndrome feature. There are more than 70 genetic types of HSP. Neuropathological studies, albeit limited to only a few genetic types of HSP, have identified axon degeneration involving the distal ends of the corticospinal tracts and fasciculus gracilis fibers. In this review, the author highlights the clinical and genetic features of HSP.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Genetic Predisposition to Disease*
  • Genetic Testing / methods
  • Genotype*
  • Humans
  • Molecular Biology / methods
  • Phenotype
  • Spastic Paraplegia, Hereditary / diagnosis*
  • Spastic Paraplegia, Hereditary / genetics*