Erythrocyte membrane fatty acids in multiple myeloma patients

Leuk Res. 2014 Oct;38(10):1260-5. doi: 10.1016/j.leukres.2014.08.009. Epub 2014 Aug 25.


Mounting data show that fatty acids (FA) and fatty acid synthase (FAS) function could be potential targets for multiple myeloma (MM) therapy. Our study aimed at comparing the FA composition of erythrocyte membranes of MM patients and healthy controls. MM patients had higher saturated FA and n-6 polyunsaturated FA (PUFA) and lower monounsaturated, n-3 PUFA and trans-FA indices than controls. The n-3/n-6 PUFA ratio was lower in MM patients and there was distinct clustering of variants of individual FA in MM patients. The FA content of erythrocyte membrane could serve as a diagnostic and/or predictive biomarker in MM.

Keywords: Cluster analysis; Erythrocyte membrane; Fatty acids; Gas chromatography; Multiple myeloma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cluster Analysis
  • Erythrocyte Membrane / chemistry*
  • Fatty Acids / analysis*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Myeloma / chemistry*


  • Fatty Acids