Urinary liver-type fatty acid-binding protein linked with increased risk of acute kidney injury after allogeneic stem cell transplantation

Biol Blood Marrow Transplant. 2014 Dec;20(12):2010-4. doi: 10.1016/j.bbmt.2014.08.022. Epub 2014 Sep 1.


Stem cell transplantation (SCT) involves a great risk of acute kidney injury (AKI). Urinary liver-type fatty acid-binding protein (uL-FABP) is a sensitive biomarker to detect kidney damage before an increase in serum creatinine (Cr); however, the utility of uL-FABP is not fully understood in the platform of SCT. A prospective study was conducted in 84 allogeneic SCT recipients to ascertain a link between the uL-FABP level before preparative procedures and AKI incidence after SCT. The association between them was analyzed using Gray's method and a multivariate Fine-Gray proportional hazards regression model. The recipients were stratified into high and low uL-FABP groups, according to the reference value for healthy subjects (8.4 μg/g Cr). AKI developed more frequently in the high (n = 20) than low (n = 64) group (55.0% versus 26.6% at day 30, P = .005), and high uL-FABP was an independent risk for the emergence of AKI (hazard ratio, 2.78; 95% confidence interval, 1.24 to 6.22, P = .01). In conclusion, increased baseline uL-FABP, which may indicate previous incipient kidney injury, is linked with a high risk of AKI after allogeneic SCT.

Keywords: Acute tubular injury; Comorbidity index; Mortality; Urinary biomarker.

Publication types

  • Comparative Study
  • Observational Study

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / urine*
  • Adolescent
  • Adult
  • Aged
  • Allografts
  • Biomarkers / blood
  • Biomarkers / urine
  • Creatinine / blood
  • Fatty Acid-Binding Proteins / urine*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Stem Cell Transplantation*


  • Biomarkers
  • FABP1 protein, human
  • Fatty Acid-Binding Proteins
  • Creatinine