Markers of a Recent Bocavirus Infection in Children With Kawasaki Disease: "A Year Prospective Study"

Pathol Biol (Paris). 2014 Dec;62(6):365-8. doi: 10.1016/j.patbio.2014.06.002. Epub 2014 Sep 2.

Abstract

Background: Retrospective studies and case-reports have suggested the possible role of various viruses in the pathogenesis of the Kawasaki disease.

Objectives: To determine prospectively the incidence of Kawasaki diseases associated with a recent bocavirus infection in the course of a year.

Study design: Thirty-two children with Kawasaki disease were enrolled in a 13 months prospective study to assess the frequency of human bocavirus type 1 infections. Seasonal shedding of virus, markers of recent infection such as viraemia, viral load, and serum interferon alpha were analyzed.

Results: Three of 32 (9%) children had HBoV-DNA in the serum suggesting a recent infection. HBoV-DNA was detected in naso-pharyngeal aspiration of 7/32 (21.8%) children with Kawasaki Disease and six of them (18%) had an increased viral load. No common respiratory viruses were isolated from the 32 patients with the exception of one adenovirus. The seven bocaviruses were identified during the winter-spring season. In addition, 4 of 7 of Kawasaki disease patients shedding bocavirus had detectable interferon alpha in the blood, indicating a possible active or recent viral infection.

Conclusions: This study shows that a recent bocavirus infection is concomitant with the onset of some cases of Kawasaki disease. Bocavirus may be a cofactor in the pathogenesis of this disease as previously reported for other infectious agents.

Keywords: Bocavirus; Interferon; Interféron; Kawasaki disease; Maladie de Kawasaki; Vascularite; Vasculitis; Viraemia; Virémie.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood*
  • Child
  • Child, Preschool
  • DNA, Viral / blood
  • Female
  • Human bocavirus* / isolation & purification
  • Human bocavirus* / physiology
  • Humans
  • Infant
  • Interferon-alpha / blood
  • Male
  • Mucocutaneous Lymph Node Syndrome / blood
  • Mucocutaneous Lymph Node Syndrome / complications*
  • Mucocutaneous Lymph Node Syndrome / epidemiology
  • Mucocutaneous Lymph Node Syndrome / virology
  • Parvoviridae Infections / blood*
  • Parvoviridae Infections / complications*
  • Parvoviridae Infections / epidemiology
  • Parvoviridae Infections / virology
  • Prospective Studies
  • Time Factors
  • Viral Load

Substances

  • Biomarkers
  • DNA, Viral
  • Interferon-alpha