Dose-response Relationship Between Polycyclic Aromatic Hydrocarbon Metabolites and Risk of Diabetes in the General Chinese Population

Environ Pollut. 2014 Dec;195:24-30. doi: 10.1016/j.envpol.2014.08.012. Epub 2014 Sep 3.

Abstract

The incidence of diabetes is increasing rapidly in Chinese population, and it has been postulated that environmental factors may play a role in the etiology of diabetes. Therefore, we aimed to investigate the association between PAHs exposure and risk of diabetes in a community-based population of 2824 participants with completed questionnaires, measurements of biochemical indices, and urinary PAHs metabolites. We found that elevated urinary PAHs metabolites were associated, in a dose-dependent manner, with increased risk of diabetes. Particularly, these associations were more evident in subjects who were female, less than 55 years old, nonsmokers, and normal weight. In addition, there was a modest improvement in diabetes discrimination of prediction models when incorporating certain PAHs metabolites into conventional risk factors (CRF). Overall, our data suggested that there may be a dose-dependent relationship between PAHs metabolites and risk of diabetes among general Chinese population.

Keywords: Diabetes; Dose-response relationship; Polycyclic aromatic hydrocarbons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • China / epidemiology
  • Diabetes Mellitus / epidemiology*
  • Dose-Response Relationship, Drug
  • Environmental Exposure / analysis
  • Environmental Exposure / statistics & numerical data*
  • Environmental Pollutants / metabolism*
  • Female
  • Humans
  • Male
  • Polycyclic Aromatic Hydrocarbons / metabolism*
  • Risk Factors

Substances

  • Environmental Pollutants
  • Polycyclic Aromatic Hydrocarbons