Significance of telomere capture in myelodysplastic syndromes

Med Oncol. 2014 Oct;31(10):216. doi: 10.1007/s12032-014-0216-0. Epub 2014 Sep 7.


Addition of telomeres to the ends of broken chromosomes has been observed in many malignant cells through the capture of the ends of other chromosomes as a result of nonreciprocal translocations. In this study, we aimed to evaluate the percentage of nuclei with telomere capture (TC%) as a prognostic marker in myelodysplastic syndromes (MDS) patients. This study included 45 newly diagnosed MDS patients, 36 cases with denovo MDS and 9 cases with therapy-related MDS, and another 35 apparently healthy volunteers as a control group. Telomere capture percentage was investigated with fluorescent in situ hybridization technique using a probe for 15qter. We found that median TC% rate was significantly increased in those with bad cytogenetic abnormalities, patients with blast cells>10% in BM, and patients categorized as high risk according to WHO and IPSS classification; also, there was a significant negative correlation with progression-free survival. Telomere capture serves as a useful marker for the assessment of MDS patient's risk, and also it had a clinical importance for the early detection of disease progression.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Chromosome Aberrations
  • Chromosomes, Human, Pair 7 / genetics
  • Disease Progression
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes / genetics*
  • Telomere / physiology*
  • Young Adult