Metabolic response to decaffeinated green tea extract during rest and moderate-intensity exercise

J Agric Food Chem. 2014 Oct 8;62(40):9936-43. doi: 10.1021/jf502764r. Epub 2014 Sep 24.


We previously reported that a 7 day ingestion of caffeinated green tea extract (cGTE) induced marked metabolic differences during rest and exercise. Here, we report the metabolic effects of 1, 7, and 28 day ingestions of decaffeinated GTE (dGTE). In this crossover placebo-controlled study, 19 healthy males ingested dGTE or placebo (PLA) for 28 days, separated by a 28 day wash-out period. On days 1, 7, and 28, participants completed a 30 min cycling exercise 2 h after the ingestion of dGTE or PLA. Blood samples were collected at rest (t = 0 and 120 min) and during exercise (t = 150 min). Plasma was analyzed using untargeted four-phase metabolite profiling and targeted profiling of catecholamines and catechins. dGTE abolished several metabolic effects when compared to our previous study with cGTE. However, following 7 and 28 day dGTE ingestions, increases in 3-hydroxybutyrate, a metabolic marker of fat oxidation, were observed at t = 0 min. dGTE ingestion did not induce significant acute or acute-on-chronic effects on endogenous metabolites just prior to and during exercise.

Keywords: caffeine; catechin; exercise; fat oxidation; green tea; metabolomics.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-Hydroxybutyric Acid / blood
  • Adipose Tissue / drug effects
  • Adipose Tissue / metabolism
  • Caffeine
  • Catechin / blood
  • Catecholamines / blood*
  • Catecholamines / metabolism
  • Dietary Supplements*
  • Energy Metabolism / drug effects
  • Exercise / physiology*
  • Humans
  • Male
  • Oxidation-Reduction
  • Rest / physiology*
  • Tea*
  • Young Adult


  • Catecholamines
  • Tea
  • Caffeine
  • Catechin
  • 3-Hydroxybutyric Acid