Development and clinical implementation of a universal bolus to maintain spot size during delivery of base of skull pencil beam scanning proton therapy

Int J Radiat Oncol Biol Phys. 2014 Sep 1;90(1):79-84. doi: 10.1016/j.ijrobp.2014.05.005.

Abstract

Purpose: To report on a universal bolus (UB) designed to replace the range shifter (RS); the UB allows the treatment of shallow tumors while keeping the pencil beam scanning (PBS) spot size small.

Methods and materials: Ten patients with brain cancers treated from 2010 to 2011 were planned using the PBS technique with bolus and the RS. In-air spot sizes of the pencil beam were measured and compared for 4 conditions (open field, with RS, and with UB at 2- and 8-cm air gap) in isocentric geometry. The UB was applied in our clinic to treat brain tumors, and the plans with UB were compared with the plans with RS.

Results: A UB of 5.5 cm water equivalent thickness was found to meet the needs of the majority of patients. By using the UB, the PBS spot sizes are similar with the open beam (P>.1). The heterogeneity index was found to be approximately 10% lower for the UB plans than for the RS plans. The coverage for plans with UB is more conformal than for plans with RS; the largest increase in sparing is usually for peripheral organs at risk.

Conclusions: The integrity of the physical properties of the PBS beam can be maintained using a UB that allows for highly conformal PBS treatment design, even in a simple geometry of the fixed beam line when noncoplanar beams are used.

MeSH terms

  • Air
  • Brain Neoplasms / radiotherapy*
  • Equipment Design / methods
  • Head and Neck Neoplasms / radiotherapy
  • Humans
  • Proton Therapy / instrumentation*
  • Proton Therapy / methods*
  • Radiotherapy Dosage
  • Radiotherapy Planning, Computer-Assisted
  • Skull Base
  • Technology, Radiologic