Synthesis of aryldiazoacetates through palladium(0)-catalyzed deacylative cross-coupling of aryl iodides with acyldiazoacetates

Fei Ye; Chengpeng Wang; Yan Zhang; Jianbo Wang

doi:10.1002/anie.201407653

Synthesis of aryldiazoacetates through palladium(0)-catalyzed deacylative cross-coupling of aryl iodides with acyldiazoacetates

Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11625-8. doi: 10.1002/anie.201407653. Epub 2014 Sep 4.

Authors

Fei Ye¹, Chengpeng Wang, Yan Zhang, Jianbo Wang

Affiliation

¹ Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871 (China).

PMID: 25196584
DOI: 10.1002/anie.201407653

Abstract

Palladium(0)-catalyzed deacylative cross-coupling of aryl iodides and acyldiazocarbonyl compounds can be achieved at room temperature under mild reaction conditions. The coupling reaction represents a highly efficient and general method for the synthesis of aryldiazocarbonyl compounds, which have found wide and increasing applications as precursors for generating donor/acceptor-substituted metallocarbenes.

Keywords: carbenes; cross-coupling; diazo compounds; palladium; synthetic methods.