Pharmacology and mechanisms of action of new oral anticoagulants

Fundam Clin Pharmacol. 2015 Feb;29(1):10-20. doi: 10.1111/fcp.12091. Epub 2014 Sep 25.


The new oral anticoagulants are announced as an important therapeutic revolution, particularly after their approval by authorities for stroke prevention in atrial fibrillation. However, the pharmacology of these new drugs is not homogeneous. In this review, we summarize the main pharmacological characteristics of the new direct anti-Xa and anti-IIa agents.

Keywords: anticoagulant; apixaban; dabigatran; edoxaban; heparin; pharmacology; rivaroxaban.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Anticoagulants / therapeutic use*
  • Atrial Fibrillation / drug therapy*
  • Humans


  • Anticoagulants