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Review
. 2014 Aug 19;12(8):4539-77.
doi: 10.3390/md12084539.

Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives

Mohammad Ferdous Mehbub  1 , Jie Lei  2 , Christopher Franco  3 , Wei Zhang  4
Affiliations
Review

Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives

Mohammad Ferdous Mehbub et al. Mar Drugs. .

Abstract

Marine sponges belonging to the phylum Porifera (Metazoa), evolutionarily the oldest animals are the single best source of marine natural products. The present review presents a comprehensive overview of the source, taxonomy, country of origin or geographical position, chemical class, and biological activity of sponge-derived new natural products discovered between 2001 and 2010. The data has been analyzed with a view to gaining an outlook on the future trends and opportunities in the search for new compounds and their sources from marine sponges.

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Figures

Figure 1
Figure 1
(a) Number of new compounds isolated from marine organisms per decade from 1970 to 2010; (b) Total number of new compounds isolated from different marine organisms from 2001 to 2010.
Figure 2
Figure 2
Total number of new compounds isolated from different types of marine sources, 2001–2010.
Figure 3
Figure 3
(a) Total number of new compounds isolated from different orders of marine sponges 2001–2010; (b) Distribution of new compounds isolated from different orders of marine sponges as a percentage found within the year, 2001–2010.
Figure 4
Figure 4
.Number of different types of genera used for isolation of new compounds from different orders of marine sponges from 2001 to 2010.
Figure 5
Figure 5
(a) Chemical classes of new compounds isolated from marine sponges from 2001 to 2010; (b) The distribution of different chemical classes of new compounds isolated from marine sponges from 2001 to 2010.
Figure 6
Figure 6
Distribution of bioactive compounds isolated from various marine sponge orders 2001–2010.
Figure 7
Figure 7
(a) Total number of new compounds isolated from different marine sponges with various bioactivities from 2001 to 2010; (b) The distribution of new compounds isolated from different orders of marine sponges with various bioactivities from 2001 to 2010.
Figure 8
Figure 8
Total number of new compounds isolated from different marine sponges and their source locations from 2001 to 2010.
Figure 9
Figure 9
Total number of new compounds isolated from marine sponges from the top 10 source countries from 2001 to 2010.
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