Orthobunyaviruses: recent genetic and structural insights

Nat Rev Microbiol. 2014 Oct;12(10):673-85. doi: 10.1038/nrmicro3332. Epub 2014 Sep 8.


Orthobunyaviruses, which have small, tripartite, negative-sense RNA genomes and structurally simple virions composed of just four proteins, can have devastating effects on human health and well-being, either by causing disease in humans or by causing disease in livestock and crops. In this Review, I describe the recent genetic and structural advances that have revealed important insights into the composition of orthobunyavirus virions, viral transcription and replication and viral interactions with the host innate immune response. Lastly, I highlight outstanding questions and areas of future research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bunyaviridae Infections / epidemiology
  • Bunyaviridae Infections / pathology
  • Bunyaviridae Infections / veterinary
  • Bunyaviridae Infections / virology*
  • Host-Pathogen Interactions*
  • Humans
  • Orthobunyavirus / genetics*
  • Orthobunyavirus / immunology
  • Orthobunyavirus / physiology*
  • Transcription, Genetic
  • Virus Replication*