Day care compared with inpatient management of nausea and vomiting of pregnancy: a randomized controlled trial

Obstet Gynecol. 2014 Oct;124(4):743-748. doi: 10.1097/AOG.0000000000000449.


Objective: To examine day care treatment of nausea and vomiting of pregnancy compared with the traditional inpatient management of this condition.

Methods: We conducted an open-label, single-center, randomized controlled trial to examine the differences between day care and inpatient management of pregnant women with nausea and vomiting of pregnancy. Primary outcome was total number of inpatient nights related to nausea and vomiting of pregnancy.

Results: Ninety-eight women were randomized to initial day care management (n=42) or inpatient management (n=56). Results are calculated from the time of randomization until resolution of nausea and vomiting of pregnancy. Women randomized to inpatient care experienced a median (interquartile range) of 2 (1-4) inpatient days compared with 0 (0-2) inpatient days for women randomized to day care (P<.001). Women randomized to initial treatment as an inpatient had significantly more median total number of inpatient admissions (one [1-2] compared with zero [0-1] admissions; P<.001) compared with women randomized to day care. No significant differences were observed in day care visits (median [interquartile range] one [1-4] compared with two [1-4]; P=.30). Women randomized to inpatient care were as satisfied with their care as those randomized to day care (median [interquartile range]: 67 [57-69] compared with 63 [58-71] Client Satisfaction Questionnaire score; P=.7).

Conclusion: Day care treatment of nausea and vomiting of pregnancy reduced hospital inpatient stay and was acceptable to patients.

Clinical trial registration: ISRCTN Register,, ISRCTN05023126.

Level of evidence: : I.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiemetics / therapeutic use*
  • Day Care, Medical / methods
  • Day Care, Medical / statistics & numerical data*
  • Female
  • Follow-Up Studies
  • Hospitalization / statistics & numerical data*
  • Hospitals, Teaching
  • Humans
  • Inpatients / statistics & numerical data
  • Ireland
  • Length of Stay
  • Morning Sickness / diagnosis
  • Morning Sickness / drug therapy*
  • Nausea / diagnosis
  • Nausea / drug therapy
  • Patient Selection
  • Pregnancy
  • Pregnancy Outcome*
  • Pregnancy Trimester, First
  • Risk Assessment
  • Tertiary Care Centers
  • Treatment Outcome
  • Ultrasonography, Prenatal / methods
  • Vomiting / diagnosis
  • Vomiting / drug therapy


  • Antiemetics

Associated data

  • ISRCTN/ISRCTN05023126