Drosophila melanogaster: a model organism for controlling Dipteran vectors and pests

J Enzyme Inhib Med Chem. 2015 Jun;30(3):505-13. doi: 10.3109/14756366.2014.944178. Epub 2014 Sep 8.


Beta-carbonic anhydrases (β-CAs) have been recently reported to be present in many protozoan and metazoan species, whereas it is absent in mammals. In this review, we introduce β-CA from Drosophila melanogaster as a model enzyme for pesticide development. These enzymes can be targeted with various enzyme inhibitors, which can have deleterious effects on pathogenic and other harmful organisms. Therefore, β-CAs represent a new potential target to fight against Dipteran vectors and pests relevant to medicine, veterinary medicine, and agriculture.

Keywords: Carbonic anhydrase; Dipteran; Drosophila melanogaster; inhibitors; pesticides.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carbonic Anhydrase Inhibitors / pharmacology*
  • Carbonic Anhydrases / metabolism*
  • Drosophila melanogaster / drug effects*
  • Drosophila melanogaster / enzymology*
  • Pesticides / pharmacology*


  • Carbonic Anhydrase Inhibitors
  • Pesticides
  • Carbonic Anhydrases