Neostigmine and pulmonary oedema

BMJ Case Rep. 2014 Sep 8:2014:bcr2014204992. doi: 10.1136/bcr-2014-204992.

Abstract

A 1-year-old child with no pre-existing cardiac or respiratory disease developed frank pulmonary oedema after administration of a neostigmine-glycopyrrolate mixture to reverse neuromuscular blockade during general anaesthesia. Possible cardiac and extra-cardiac factors that could cause pulmonary oedema in this child were ruled out by appropriate investigations. As the pulmonary oedema manifested shortly after administration of the neostigmine-glycopyrrolate mixture, we concluded that neostigmine was the most probable cause. This article briefly reports the occurrence of events and successful management of perioperative pulmonary oedema.

Publication types

  • Case Reports

MeSH terms

  • Anesthesia, General
  • Cholinesterase Inhibitors / adverse effects*
  • Cholinesterase Inhibitors / therapeutic use
  • Glycopyrrolate / administration & dosage
  • Humans
  • Infant
  • Neostigmine / adverse effects*
  • Neostigmine / therapeutic use
  • Postoperative Complications* / drug therapy
  • Pulmonary Edema / chemically induced*

Substances

  • Cholinesterase Inhibitors
  • Neostigmine
  • Glycopyrrolate