[Intrathecal baclofen therapy and management of severe spasticity]

Brain Nerve. 2014 Sep;66(9):1049-55.
[Article in Japanese]

Abstract

Continuous infusion of intrathecal baclofen (ITB), via implanted pump, is a powerful tool in the management of severe spasticity in neurological disorders. The advantages of ITB therapy are that it is non-destructive, reversible, and programmable, allowing for neuromodulation. Patients reported significant subjective improvements and decreases in muscle tone after baclofen injection, but excessive doses of ITB resulted in motor weakness. Few complications and adverse effects were reported. ITB therapy appears to be a promising treatment to improve residual motor control in patients with severe spasticity.

Publication types

  • English Abstract

MeSH terms

  • Baclofen / administration & dosage
  • Baclofen / adverse effects
  • Baclofen / chemistry
  • Baclofen / therapeutic use*
  • Humans
  • Injections, Spinal
  • Muscle Relaxants, Central / administration & dosage
  • Muscle Relaxants, Central / adverse effects
  • Muscle Relaxants, Central / chemistry
  • Muscle Relaxants, Central / therapeutic use*
  • Muscle Spasticity / drug therapy*
  • Patient Selection
  • Walking

Substances

  • Muscle Relaxants, Central
  • Baclofen