Casein kinase 1 and Wnt/β-catenin signaling

Curr Opin Cell Biol. 2014 Dec;31:46-55. doi: 10.1016/j.ceb.2014.08.003. Epub 2014 Sep 15.

Abstract

Casein kinase 1 (CK1) members play a critical and evolutionary conserved role in Wnt/β-catenin signaling. They phosphorylate several pathway components and exert a dual function, acting as both Wnt activators and Wnt inhibitors. Recent discoveries suggest that CK1 members act in a coordinated manner to regulate early responses to Wnt and notably that their enzymatic activity is regulated. Here, I provide a brief update of CK1 function and regulation in Wnt/β-catenin signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Casein Kinase I / metabolism*
  • Humans
  • Phosphorylation
  • Signal Transduction*
  • Wnt Proteins / metabolism
  • Wnt Signaling Pathway*
  • beta Catenin / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Wnt Proteins
  • beta Catenin
  • Casein Kinase I