Radiotherapy with soft X-rays in Dupuytren's disease - successful, well-tolerated and satisfying

J Eur Acad Dermatol Venereol. 2015 May;29(5):904-11. doi: 10.1111/jdv.12711. Epub 2014 Sep 8.


Background: Up to present no curative treatment is known for Dupuytren's disease (DD). Surgery remains the most common treatment but lack of long-term efficacy and complications limit this therapeutic option.

Objective: In a retrospective analysis, the results of radiotherapy with soft X-rays in the treatment of DD were evaluated.

Methods: A total of 206 patients (297 affected hands) with DD were included. Radiation therapy was carried out with soft X-rays. A structured questionnaire considering patient and disease characteristics and effects of radiotherapy was evaluated after a median follow-up time of 40 months.

Results: Ninety-three (45%) of the 206 treated patients were reported on a regression of symptoms after radiation. No further disease progression (including patients with regression) was present in 165 patients (80%). Satisfaction with the therapy was expressed with an average score of 7.9 points (visual analogue scale, 0 = not satisfied, 10 = extremely satisfied). Subjective therapeutic effects for 426 nodules and/or cords showed a reduction of 92 nodules and/or cords.

Conclusion: In 206 DD patients further disease progression was stopped in most patients. Radiotherapy proved to be well-tolerated, successful and satisfying for the patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dupuytren Contracture / genetics
  • Dupuytren Contracture / radiotherapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Satisfaction
  • Radiotherapy / adverse effects
  • Retrospective Studies
  • Surveys and Questionnaires
  • Treatment Outcome