Impact of locoregional treatment on survival in patients presented with metastatic breast carcinoma

Breast. 2014 Dec;23(6):775-83. doi: 10.1016/j.breast.2014.08.008. Epub 2014 Sep 5.


Objectives: In this study, we tried to evaluate the efficacy of locoregional treatment (LRT) in patients with metastatic breast carcinoma (MBC).

Materials and methods: The medical records of 227 patients with MBC at initial presentation between April 1999 and January 2013 were retrospectively evaluated. The median age at diagnosis was 50 years (range, 27-83 years). Thirty-nine patients (17%) had no LRT. Among patients who had LRT, 2 (1%) had locoregional radiotherapy (RT) alone, 54 (29%) had surgery alone [mastectomy, n = 50; breast conserving surgery (BCS), n = 4] and 132 (70%) had surgery (mastectomy, n = 119; BCS, n = 13) followed by locoregional RT.

Results: The median follow-up time was 35 months (range, 4-149 months). Five-year OS and PFS rates were 44% and 20%, respectively. In both univariate and multivariate analysis LRT per se did not affect OS and PFS rates. However, the 5-year OS and PFS rates were significantly higher in patients treated with locoregional RT than the ones who were not. The corresponding rates were 56% vs. 24% for OS and 27% vs. 7% for PFS (p < 0.001). Median survival was 67 months and 37 months, respectively.

Conclusion: Our study showed that patients with MBC who received postoperative locoregional RT may have a survival advantage compared with patients who were only treated by surgery. A phase III trial testing the role of adjuvant locoregional RT may help to distinguish patients who will benefit from adjuvant RT.

Keywords: Chemotherapy; Locoregional treatment; Metastatic breast carcinoma; Radiotherapy; Surgery.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy*
  • Carcinoma, Ductal, Breast / pathology
  • Carcinoma, Ductal, Breast / therapy*
  • Carcinoma, Lobular / pathology
  • Carcinoma, Lobular / therapy*
  • Disease-Free Survival
  • Female
  • Humans
  • Mastectomy*
  • Mastectomy, Segmental
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Radiotherapy
  • Radiotherapy, Adjuvant
  • Retrospective Studies
  • Treatment Outcome