The intercellular cell adhesion molecule-1 (icam-1) in lung cancer: implications for disease progression and prognosis

Abstract

The intercellular cell-adhesion molecule-1 (ICAM-1) is a transmembrane molecule and a distinguished member of the Immunoglobulin superfamily of proteins that participates in many important processes, including leukocyte endothelial transmigration, cell signaling, cell-cell interaction, cell polarity and tissue stability. ICAM-1and its soluble part are highly expressed in inflammatory conditions, chronic diseases and a number of malignancies. In the present article we present the implications of ICAM-1 in the progression and prognosis of one of the major global killers of our era: lung cancer.

Keywords: Intercellular cell-adhesion molecule; cell polarity; cell signaling; cell-cell interaction; immunoglobulin; lung cancer; prognosis; review.