Plasmablastic lymphoma of the breast in an immunocompetent patient: long-lasting complete response induced by chemotherapy and autologous stem cell trasplantation

Anticancer Res. 2014 Sep;34(9):5111-5.


Background: Plasmablastic lymphoma (PBL) is a rare entity which is often causally related to infection by the Human Immunodeficiency Virus (HIV). Despite its predilection for oral cavity involvement, multiple cases of extra-oral involvement have been reported in the literature, more often among immunocompetent individuals.

Case report: Herein we present the first case of primary PBL of the breast in an otherwise immunocompetent 36-year-old woman who was successfully treated with consolidation megatherapy and autologous stem cell transplantation.

Conclusion: PBL carries a particularly poor prognosis and more intensive treatment is usually warranted. However, no treatment guidelines exist and treatment choices are made based on case reports and small retrospective case series.

Keywords: HIV; Plasmablastic lymphoma; autologous transplant; breast.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / therapy
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Immunohistochemistry
  • Induction Chemotherapy
  • Mammography
  • Plasmacytoma / diagnosis*
  • Plasmacytoma / therapy
  • Transplantation, Autologous
  • Treatment Outcome