Centromere licensing: Mis18 is required to Polo-ver

Curr Biol. 2014 Sep 8;24(17):R808-10. doi: 10.1016/j.cub.2014.07.026.


The Mis18 complex is a critical player in determining when and where centromeres are built. A new study identifies Polo-like kinase (Plk1) as a positive regulator required for the localization of Mis18 to centromeres. This is a critical step that is essential for proper centromere function and maintaining the integrity of the genome.

Publication types

  • Comment

MeSH terms

  • Autoantigens / metabolism*
  • Cell Cycle Proteins / metabolism*
  • Centromere / metabolism*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Humans
  • Protein Serine-Threonine Kinases / metabolism*
  • Proto-Oncogene Proteins / metabolism*


  • Autoantigens
  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • Proto-Oncogene Proteins
  • Protein Serine-Threonine Kinases