Hopping-mediated anion transport through a mannitol-based rosette ion channel

J Am Chem Soc. 2014 Oct 8;136(40):14128-35. doi: 10.1021/ja506278z. Epub 2014 Sep 23.


Artificial anion selective ion channels with single-file multiple anion-recognition sites are rare. Here, we have designed, by hypothesis, a small molecule that self-organizes to form a barrel rosette ion channel in the lipid membrane environment. Being amphiphilic in nature, this molecule forms nanotubes through intermolecular hydrogen bond formation, while its hydrophobic counterpart is stabilized by hydrophobic interactions in the membrane. The anion selectivity of the channel was investigated by fluorescence-based vesicle assay and planar bilayer conductance measurements. The ion transport by a modified hopping mechanism was demonstrated by molecular dynamics simulation studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Biomimetic Materials / chemistry*
  • Cell Membrane / metabolism
  • Hydrogen Bonding
  • Hydroxides / chemistry
  • Ion Channels / metabolism*
  • Ion Transport
  • Mannitol / chemistry*
  • Models, Molecular
  • Molecular Conformation
  • Thermodynamics


  • Hydroxides
  • Ion Channels
  • Mannitol
  • hydroxide ion