Brush-like polycarbonates containing dopamine, cations, and PEG providing a broad-spectrum, antibacterial, and antifouling surface via one-step coating

Adv Mater. 2014 Nov 19;26(43):7346-51. doi: 10.1002/adma.201402059. Epub 2014 Sep 10.

Abstract

An antibacterial and antifouling surface is obtained by simple one-step immersion of a catheter surface with brush-like polycarbonates containing pendent adhesive dopamine, antifouling polyethylene glycol (PEG), and antibacterial cations. This coating demonstrates excellent antibacterial and antifouling activities against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria, proteins, and platelets, good stability under simulated blood-flow conditions, and no toxicity.

Keywords: antibacterial; antifouling; catheter coating; cationic polycarbonates; long term efficacy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Adhesion / drug effects
  • Catheters*
  • Cations / chemistry
  • Cations / pharmacology*
  • Cattle
  • Cell Count
  • Dopamine / chemistry
  • Dopamine / pharmacology*
  • Escherichia coli / drug effects
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Models, Biological
  • Polycarboxylate Cement / chemistry
  • Polycarboxylate Cement / pharmacology*
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / pharmacology*
  • Serum Albumin, Bovine / chemistry
  • Silicones / chemistry
  • Staphylococcus aureus / drug effects
  • Static Electricity

Substances

  • Anti-Bacterial Agents
  • Cations
  • Polycarboxylate Cement
  • Silicones
  • polycarbonate
  • Serum Albumin, Bovine
  • Polyethylene Glycols
  • Dopamine