Abstract
An antibacterial and antifouling surface is obtained by simple one-step immersion of a catheter surface with brush-like polycarbonates containing pendent adhesive dopamine, antifouling polyethylene glycol (PEG), and antibacterial cations. This coating demonstrates excellent antibacterial and antifouling activities against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria, proteins, and platelets, good stability under simulated blood-flow conditions, and no toxicity.
Keywords:
antibacterial; antifouling; catheter coating; cationic polycarbonates; long term efficacy.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Bacterial Adhesion / drug effects
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Catheters*
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Cations / chemistry
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Cations / pharmacology*
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Cattle
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Cell Count
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Dopamine / chemistry
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Dopamine / pharmacology*
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Escherichia coli / drug effects
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Materials Testing
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Microscopy, Electron, Scanning
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Models, Biological
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Polycarboxylate Cement / chemistry
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Polycarboxylate Cement / pharmacology*
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Polyethylene Glycols / chemistry
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Polyethylene Glycols / pharmacology*
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Serum Albumin, Bovine / chemistry
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Silicones / chemistry
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Staphylococcus aureus / drug effects
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Static Electricity
Substances
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Anti-Bacterial Agents
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Cations
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Polycarboxylate Cement
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Silicones
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polycarbonate
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Serum Albumin, Bovine
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Polyethylene Glycols
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Dopamine