Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Apr;21(2):69-73.
doi: 10.5214/ans.0972.7531.210208.

The Social Brain Network and Autism

Affiliations
Free PMC article
Review

The Social Brain Network and Autism

Vivek Misra. Ann Neurosci. .
Free PMC article

Abstract

Available research data in Autism suggests the role of a network of brain areas, often known as the 'social brain'. Recent studies highlight the role of genetic mutations as underlying patho-mechanism in Autism. This mini review, discusses the basic concepts behind social brain networks, theory of mind and genetic factors associated with Autism. It critically evaluates and explores the relationship between the behavioral outcomes and genetic factors providing a conceptual framework for understanding of autism.

Keywords: Autism; Behavioral Genetics; Brain Networks.

Figures

Fig. 1:
Fig. 1:
Proteins with genetic variants associated with autism spectrum disorder (ASD) (excluding those in white ovals) are clustered in specific intracellular processes. In colour, proteins with genetic variants associated with ASD; in white, proteins not directly associated with ASD. From Ghosh et al., Nat Rev Drug Discov. 2013;12(10):777-90. Reprinted with permission.

Similar articles

See all similar articles

Cited by 5 articles

References

    1. Hutsler J, Zhang H. Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders. Brain research. 2010;1309:83–94. - PubMed
    1. Casanova M, Buxhoeveden D, Switala A et al. Neuronal density and architecture (Gray Level Index) in the brains of autistic patients. Journal of child neurology. 2002;17(7):515–21. - PubMed
    1. Schultz R. Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area. International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience. 2005;23(2–3):125–41. - PubMed
    1. Grelotti D, Klin A, Gauthier I et al. fMRI activation of the fusiform gyrus and amygdala to cartoon characters but not to faces in a boy with autism. Neuropsychologia. 2005;43(3):373–85. - PubMed
    1. Pelphrey K, Morris J, McCarthy G. Neural basis of eye gaze processing deficits in autism. Brain: a journal of neurology. 2005;128(Pt 5):1038–48. - PubMed

LinkOut - more resources

Feedback