Antiviral activity of ancient system of ayurvedic medicinal plant Cissus quadrangularis L. (Vitaceae)

P Balasubramanian; K Jayalakshmi; N Vidhya; R Prasad; A Khaleefathullah Sheriff; G Kathiravan; K Rajagopal; Sripathi M Sureban

Antiviral activity of ancient system of ayurvedic medicinal plant Cissus quadrangularis L. (Vitaceae)

J Basic Clin Pharm. 2009 Dec;1(1):37-40. Epub 2010 Feb 15.

Authors

P Balasubramanian¹, K Jayalakshmi², N Vidhya², R Prasad¹, A Khaleefathullah Sheriff³, G Kathiravan¹, K Rajagopal¹, Sripathi M Sureban⁴

Affiliations

¹ Department of Biotechnology, VELS University, Old Pallavaram, Chennai-600117, Tamil Nadu, India.
² Department of Biotechnology, Vel's College of Science, Old Pallavaram, Chennai-600117, Tamil Nadu, India.
³ Department of Virology, King Institute of Preventive Medicine, Guindy, Chennai-600032, Tamil Nadu, India.
⁴ Department of Medicine, Digestive Diseases and Nutrition Section, The University of Oklahoma Health Sciences Center, Oklahoma 73104, USA. ; Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.

PMID: 25206252
PMCID: PMC4158892

Abstract

Partially purified methanolic extract of Cissus quadrangularis (belonging to Vitaceae member, South Indian medicinal plant) have been explored for antiviral activity and their phytochemical characterisation. In vitro antiviral activity against HSV type1 and 2, and Vero cells at non-cytotoxic concentration were determined. HSV1 and HSV2 showed more sensitivity against the partially purified compound. Phytochemical analysis showed the presence of the Steroids and Terpenoids.

Keywords: Antiviral; Ayurvedic; Cissus quadrangularis; HSV; Influenza virus.