Angiotensin-converting enzyme gene polymorphism and middle cerebral artery stenosis in a Chinese Han population

Chunshu Rong; Yingqi Xing; Xinmei Jiang; Juan Wang; Baoshan Gao; Jianjun Zhao; Kangding Liu

doi:10.3969/j.issn.1673-5374.2013.15.008

Angiotensin-converting enzyme gene polymorphism and middle cerebral artery stenosis in a Chinese Han population

Neural Regen Res. 2013 May 25;8(15):1410-7. doi: 10.3969/j.issn.1673-5374.2013.15.008.

Authors

Chunshu Rong¹, Yingqi Xing², Xinmei Jiang², Juan Wang², Baoshan Gao³, Jianjun Zhao⁴, Kangding Liu²

Affiliations

¹ Department of Encephalopathy, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, Jilin Province, China ; Department of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
² Department of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
³ Department of Urinary Surgery, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
⁴ Department of Encephalopathy, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, Jilin Province, China.

PMID: 25206436
PMCID: PMC4107760
DOI: 10.3969/j.issn.1673-5374.2013.15.008

Abstract

The angiotensin-converting enzyme gene is a candidate gene of stroke. The present study involved 62 healthy volunteers and 148 patients with middle cerebral artery stenosis as confirmed by brain color ultrasound from a Han population in North China, and determined the peripheral blood angiotensin-converting enzyme genotype using PCR-restriction fragment length polymorphism analysis. The results showed that the frequencies of the DD genotype and D allele were increased in patients with middle cerebral artery stenosis, but the difference was not statistically significant compared with healthy controls. The findings of this study on the relationship between stroke genes and middle cerebral artery stenosis indicate no significant correlation between the frequencies of the DD genotype and D allele of angiotensin-converting enzyme and middle cerebral artery stenosis in this Han population from North China. In the future, studies will be carried out to investigate correlations between multiple stroke candidate gene synergy and middle cerebral artery stenosis to provide a foundation for the development of gene therapy.

Keywords: Han population; North China; angiostenosis; angiotensin-converting enzyme; brain injury; gene; middle cerebral artery; neural regeneration; neuroregeneration; polymorphism; stroke.