Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jul 25;8(21):1958-65.
doi: 10.3969/j.issn.1673-5374.2013.21.004.

Regional Gray Matter Atrophy and Neuropsychologcal Problems in Relapsing-Remitting Multiple Sclerosis

Affiliations
Free PMC article

Regional Gray Matter Atrophy and Neuropsychologcal Problems in Relapsing-Remitting Multiple Sclerosis

Aiyu Lin et al. Neural Regen Res. .
Free PMC article

Abstract

In multiple sclerosis, gray matter atrophy is extensive, and cognitive deficits and mood disorders are frequently encountered. It has been conjectured that focal atrophy is associated with emotional decline. However, conventional MRI has revealed that the pathological characteristics cannot fully account for the mood disorders. Moreover, there is no correlation between cognitive disorders and MRI results in clinically isolated syndromes or in cases of definite multiple sclerosis. In this case-control study, voxel-based morphometric analysis was performed on 11 subjects with relapsing-remitting multiple sclerosis, and the results show that these patients exhibit gray matter atrophy. Moreover, the gray matter atrophy in the superior and middle gyri of the right frontal lobe in patients with multiple sclerosis was correlated with scores from the Hamilton Anxiety Rating Scale. The scores obtained with the Repeatable Battery for the Assessment of Neuropsychological Status were associated with gray matter atrophy in the middle gyrus of the left frontal lobe, the superior and middle gyrus of the right frontal lobe, the middle gyrus of the left cingulate, the superior and middle gyri of the left frontal lobe, and the triangular area of the left frontal lobe. However, there was no statistical significance. These findings suggest that the cingulate and frontal cortices of the nant hemisphere are the most severely atrophic regions of the brain, and this atrophy is correlated with cognitive decline and emotional abnormalities.

Keywords: MRI; cognitive; gray matter atrophy; mood; neural regeneration; neurodegeneration; neuroregeneration; relapsing-remitting multiple sclerosis; voxel-based morphometry.

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Gray matter atrophy in relapsing-remitting multiple sclerosis patients by MRI. Voxel-based morphometric analysis showed that the volume of the gray matter in the multiple sclerosis group was significantly reduced compared with the healthy control group. Map of yellow dots represents significant parts of gray matter atrophy. The atrophy was most significant in the cingulate and frontal cortices of the dominant hemisphere. The atrophic brain regions in the automated anatomical labeling template included the following lobes: Cingulum_Mid_L (A): Median cingulate and paracingulate gyri left; Frontal_Sup_Medial_R (B): Superior frontal gyrus, medial right; Frontal_Inf_Tri_L (C): Inferior frontal gyrus, triangular part left; Frontal_Mid_L (D): Middle frontal gyrus left, and Frontal_Sup_Medial _L (E): Superior frontal gyrus, medial left.

Similar articles

See all similar articles

Cited by 2 articles

References

    1. Wasay M, Khatri IA, Khealani B, et al. MS in Asian countries. Int MS J. 2006;13(2):58–65. - PubMed
    1. Feinstein A, Youl B, Ron M. Acute optic neuritis. A cognitive and magnetic resonance imaging study. Brain. 1992;115(Pt 5):1403–1415. - PubMed
    1. Giorgio A, De Stefano N. Cognition in multiple sclerosis: relevance of lesions, brain atrophy and proton MR spectroscopy. Neurol Sci. 2010;31(Suppl 2):S245–248. - PubMed
    1. De Stefano N, Matthews PM, Filippi M, et al. Evidence of early cortical atrophy in MS: relevance to white matter changes and disability. Neurology. 2003;60(7):1157–1162. - PubMed
    1. Khalil M, Enzinger C, Langkammer C, et al. Cognitive impairment in relation to MRI metrics in patients with clinically isolated syndrome. Mult Scler. 2011;17(2):173–180. - PubMed

LinkOut - more resources

Feedback