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Case Reports
, 47 (3), 320-4

Extraskeletal Osteosarcoma Arising From the Pleura

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Case Reports

Extraskeletal Osteosarcoma Arising From the Pleura

Chee-Hoon Lee et al. Korean J Thorac Cardiovasc Surg.

Abstract

A 37-year-old woman was referred to our institution for further management of a mass lesion located in the thoracic cavity. The mass had grown by more than 10 cm over the course of a year and was initially considered to be a scar from previous pulmonary tuberculosis at another hospital. The patient had complained of left-sided flank pain for a year and experienced dyspnea for one month. Chest radiography and chest computed tomography revealed an irregular-shaped mass in the left mid to lower pleural cavity. The mass was widely excised through left thoracotomy. Pathologic examination of the biopsy specimen revealed a malignant spindle cell tumor, which consisted of components of osteosarcoma, pleomorphic sarcoma, and leiomyosarcoma. The patient underwent adjuvant chemotherapy and has been doing well without any evidence of recurrence for 14 months.

Keywords: 1. Pleura; 2. Extraskeletal osteosarcoma.

Figures

Fig. 1
Fig. 1
Chest radiograph that was carried out: (A) at another hospital eight months previously and (B) at the time of admission. Chest computed tomography revealed two separated tumors. (C) A 4-cm mass adjacent to inner side of the shaft of the 6th rib and (D) an 8-cm mass located at the costophrenic angle.
Fig. 2
Fig. 2
Operative findings and gross findings of the mass. (A) Radical excision of the tumor involved wedge resection of the left lower lobe of the lung (arrow) and partial resection of the diaphragm (arrowhead). (B) After removal, the tumors showed a hard surface and an irregular margin, and the mass contained calcification.
Fig. 3
Fig. 3
Microscopic findings of the mass. (A) Differences in nuclei size and shape (H&E, ×100). (B) Smooth muscle differentiation (H&E, ×200). (C) Osteoid production cells (H&E, ×400). (D) Smooth muscle actin detection (immunohistochemistry stain, ×200).

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