Role of IL1A rs1800587, IL1B rs1143627 and IL1RN rs2234677 genotype regarding development of chronic lumbar radicular pain; a prospective one-year study

PLoS One. 2014 Sep 10;9(9):e107301. doi: 10.1371/journal.pone.0107301. eCollection 2014.

Abstract

Previous studies indicate that lumbar radicular pain following disc herniation may be associated with release of several pro-inflammatory mediators, including interleukin-1 (IL1). In the present study, we examined how genetic variability in IL1A (rs1800587 C>T), IL1B (rs1143627 T>C) and IL1RN (rs2234677 G>A) influenced the clinical outcome the first year after disc herniation. Patients (n = 258) with lumbar radicular pain due to disc herniation were recruited from two hospitals in Norway. Pain and disability were measured by visual analogue scale (VAS) and Oswestry Disability Index (ODI) over a 12 month period. The result showed that patients with the IL1A T allele, in combination with the IL1RN A allele had more pain and a slower recovery than other patients (VAS p = 0.049, ODI p = 0.059 rmANOVA; VAS p = 0.003, ODI p = 0.050 one-way ANOVA at 12 months). However, regarding the IL1B/IL1RN genotype, no clear effect on recovery was observed (VAS p = 0.175, ODI p = 0.055 rmANOVA; VAS p = 0.105, ODI p = 0.214 one-way ANOVA at 12 months). The data suggest that the IL1A T/IL1RN A genotype, but not the IL1B T/IL1RN A genotype, may increase the risk of a chronic outcome in patients following disc herniation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • Chronic Pain / etiology
  • Chronic Pain / genetics*
  • Chronic Pain / physiopathology
  • Chronic Pain / surgery
  • Disability Evaluation
  • Female
  • Genotype
  • Humans
  • Interleukin 1 Receptor Antagonist Protein / genetics*
  • Interleukin-1alpha / genetics*
  • Interleukin-1beta / genetics*
  • Intervertebral Disc Displacement / complications
  • Intervertebral Disc Displacement / genetics*
  • Intervertebral Disc Displacement / physiopathology
  • Intervertebral Disc Displacement / surgery
  • Low Back Pain / etiology
  • Low Back Pain / genetics*
  • Low Back Pain / physiopathology
  • Low Back Pain / surgery
  • Lumbar Vertebrae / injuries
  • Lumbar Vertebrae / physiopathology
  • Lumbar Vertebrae / surgery
  • Male
  • Middle Aged
  • Norway
  • Pain Measurement
  • Polymorphism, Single Nucleotide*
  • Quality of Life
  • Surveys and Questionnaires

Substances

  • IL1A protein, human
  • IL1B protein, human
  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1alpha
  • Interleukin-1beta

Grant support

These authors have no support or funding to report.