Abstract
9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp(3))-H and C(sp(2))-H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acridines / chemistry
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Acrylates / chemical synthesis
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Acrylates / chemistry
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Alkylation
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Amides / chemistry*
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Catalysis
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Iodides / chemistry*
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Ligands
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Palladium / chemistry*
Substances
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Acridines
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Acrylates
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Amides
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Iodides
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Ligands
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N-methylacridine
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Palladium