Effect of transcutaneous aortic valve implantation on the Heyde's syndrome

Am J Cardiol. 2014 Sep 15;114(6):953-4. doi: 10.1016/j.amjcard.2014.06.025. Epub 2014 Jul 2.


The association between aortic valve stenosis and gastrointestinal bleeding, traditionally known as Heyde's syndrome, is the result of a quantitative loss of the highest molecular weight von Willebrand multimers (type 2A von Willebrand syndrome). This results in bleeding from areas of high shear stress such as gastrointestinal angiodysplasias. Correction of this bleeding diathesis after surgical aortic valve replacement has been well described. The effect of transcutaneous aortic valve implantation on Heyde's syndrome has yet to be studied. Herein, we report a patient with severe aortic stenosis, type 2A von Willebrand syndrome, and hemorrhagic shock from gastrointestinal bleeding who underwent successful transcutaneous aortic valve implantation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aortic Valve Stenosis / complications
  • Aortic Valve Stenosis / diagnostic imaging
  • Aortic Valve Stenosis / surgery*
  • Echocardiography
  • Follow-Up Studies
  • Gastrointestinal Hemorrhage / complications*
  • Heart Valve Prosthesis Implantation / methods*
  • Hemostasis / physiology
  • Humans
  • Male
  • Recovery of Function
  • Syndrome
  • von Willebrand Disease, Type 2 / blood
  • von Willebrand Disease, Type 2 / etiology*
  • von Willebrand Factor / metabolism


  • von Willebrand Factor