Differential uptake of Tc-99m DMSA and Tc-99m EC in renal tubular disorders: Report of two cases and review of the literature

Indian J Nucl Med. 2014 Jul;29(3):160-2. doi: 10.4103/0972-3919.136571.


Tc-99m DMSA and Tc-99m EC studies are invaluable functional imaging modalities for renal structural and functional assessment. Normally, the relative renal function estimated by the two methods correlates well with each other. We here present two patients with renal tubular acidosis who showed impaired/altered DMSA uptake with normal EC renal dynamic study depicting the pitfall of DMSA imaging in tubular disorders. The two presented cases also depict distinct pattern of Tc-99m DMSA scintigraphic findings in patients with proximal and distal renal tubular acidosis, thus highlighting the factors affecting DMSA kinetics.

Keywords: Fanconi syndrome; Lowe syndrome; Tc-99m DMSA scan; Tc-99m EC scan; renal tubular acidosis.

Publication types

  • Case Reports