10-Hydroxynortriptyline and treatment effects in elderly depressed patients

J Neuropsychiatry Clin Neurosci. 1989 Spring;1(2):176-80. doi: 10.1176/jnp.1.2.176.


Sixty-four elderly depressed outpatients were treated with nortriptyline for seven weeks. Plasma nortriptyline and its main metabolite, 10-hydroxynortriptyline, were measured weekly. No relationship was found between levels of 10-hydroxynortriptyline and clinical response. Plasma levels of the trans isomer, E-10-hydroxynortriptyline, were significantly lower when dizziness and symptoms of orthostatic hypotension were reported, although there was no significant correlation with actual orthostatic drop in systolic pressure. Plasma level of 10-hydroxynortriptyline was not significantly correlated with the other reported side effects.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Depressive Disorder / blood
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / psychology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nortriptyline / analogs & derivatives*
  • Nortriptyline / pharmacokinetics
  • Nortriptyline / therapeutic use*
  • Personality Inventory
  • Phenelzine / pharmacokinetics
  • Phenelzine / therapeutic use
  • Single-Blind Method
  • Stereoisomerism


  • 10-hydroxynortriptyline
  • Nortriptyline
  • Phenelzine