New and bioactive lignans from the fruits of Schisandra sphenanthera

Hsin-Chan Huang; Yu-Chi Lin; Ahmed Eid Fazary; I-Wen Lo; Chia-Ching Liaw; Yi-Zsau Huang; Shorong-Shii Liou; Ya-Ching Shen

doi:10.1016/j.foodchem.2011.03.030

New and bioactive lignans from the fruits of Schisandra sphenanthera

Food Chem. 2011 Sep 15;128(2):348-57. doi: 10.1016/j.foodchem.2011.03.030. Epub 2011 Mar 12.

Authors

Hsin-Chan Huang¹, Yu-Chi Lin¹, Ahmed Eid Fazary¹, I-Wen Lo¹, Chia-Ching Liaw¹, Yi-Zsau Huang², Shorong-Shii Liou³, Ya-Ching Shen⁴

Affiliations

¹ School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
² National Research Institute of Chinese Medicine, Taipei, Taiwan.
³ Department of Pharmacy, Tajen University, Ping-Tung, Taiwan.
⁴ School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: ycshen@ntu.edu.tw.

PMID: 25212141
DOI: 10.1016/j.foodchem.2011.03.030

Abstract

Phytochemical investigation of the ethanol extract from the fruits of Schisandra sphenanthera has resulted in isolation of seven new oxygenated lignans (1-7), in addition to 11 known compounds (8-18). Their structures were determined on the basis of 2D-NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated components were evaluated with a reporter gene assay that measures their anti-liver fibrosis activity. Compounds 1, 2, 4, 11, 13, 14 and 18 exhibited significant anti-inflammatory activity on HSC-T6 test.

Keywords: Anti-liver fibrosis activity; Aryltetralone lignans; Dibenzocyclooctadienes; Schisandra sphenanthera.