COMPLEMENTing the diagnosis of aHUS

Blood. 2014 Sep 11;124(11):1699-700. doi: 10.1182/blood-2014-07-590356.

Abstract

In this issue of Blood, Noris et al describe a functional complement assay that can be used to diagnose atypical hemolytic-uremic syndrome (aHUS). This assay might also be useful in identifying aHUS patients in remission and in detecting asymptomatic carriers of complement gene mutations. Besides being used for diagnostic purposes, this assay potentially can be used to monitor anticomplement therapy.

Publication types

  • Comment

MeSH terms

  • Antibodies, Monoclonal, Humanized / administration & dosage*
  • Atypical Hemolytic Uremic Syndrome
  • Complement Activation / drug effects*
  • Female
  • Hemolytic-Uremic Syndrome / blood*
  • Hemolytic-Uremic Syndrome / drug therapy*
  • Humans
  • Male
  • Monitoring, Physiologic*

Substances

  • Antibodies, Monoclonal, Humanized
  • eculizumab