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. 2014 Sep 12;345(6202):1240-1.
doi: 10.1126/science.1252966.

RNA Function. RNA and dynamic nuclear organization

John Rinn  1 , Mitchell Guttman  2
Affiliations

RNA Function. RNA and dynamic nuclear organization

John Rinn et al. Science. .
No abstract available

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Figures

Figure 1
Figure 1. An RNA roadmap to nuclear organization
Cutaway of the nucleus highlighting three organizational levels: active (left) and inactive (bottom) regions, and nuclear bodies (right). Clockwise from right to left: The nucleolus is formed around actively transcribed rRNA sites; paraspeckles are formed by the Neat1 lncRNA; the Malat1 lncRNA is present within the nuclear speckle, and actively transcribed genes are repositioned close to nuclear speckles; the inactive X chromosome (Barr body) is coated by the Xist lncRNA and dynamically repositioned from the active to inactive compartments where it is localized to the periphery of the nucleus; lncRNAs can mediate gene-gene interactions across chromosomes (bottom panel inset) and within chromosomes (top panel inset).
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