SnapShot: FMRP mRNA targets and diseases

Cell. 2014 Sep 11;158(6):1446-1446.e1. doi: 10.1016/j.cell.2014.08.035.


FMRP, or fragile X mental retardation protein is an RNA-binding protein. Mutations in the FMRP protein have been associated with neurological disease as have a number of its mRNA-binding targets. This SnapShot presents 40 bona fide FMRP targets for which mRNA binding and protein regulation have been robustly reported in mammals along with the diseases with which they have been associated.

MeSH terms

  • Animals
  • Brain Diseases / genetics*
  • Brain Diseases / metabolism
  • Fragile X Mental Retardation Protein / metabolism*
  • Humans
  • Mental Disorders / genetics*
  • Mental Disorders / metabolism
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • RNA, Messenger / metabolism*


  • RNA, Messenger
  • Fragile X Mental Retardation Protein