Molecular mechanisms for contribution of MHC molecules to autoimmune diseases

Curr Opin Immunol. 2014 Dec;31:24-30. doi: 10.1016/j.coi.2014.08.005. Epub 2014 Sep 15.


It will soon be 50 years since the first MHC associations with human disease were described. These seminal studies opened a flourishing area of research, yet much remains to be discovered. Genome-wide association studies of autoimmune diseases have demonstrated that the MHC region has effect sizes that supersede those for any non-MHC locus for most diseases. Thus, an understanding of how particular MHC alleles confer susceptibility will be essential for a comprehensive understanding of autoimmune disease pathogenesis. Here we review recent exciting findings in this important field.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / genetics*
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / pathology
  • Histocompatibility Antigens / genetics*
  • Histocompatibility Antigens / immunology*
  • Humans
  • Major Histocompatibility Complex / immunology*


  • Histocompatibility Antigens