Models for measuring anthelmintic drug efficacy for parasitologists

Trends Parasitol. 2014 Nov;30(11):528-37. doi: 10.1016/j.pt.2014.08.004. Epub 2014 Sep 11.

Abstract

Anthelmintic drug efficacy (ADE) is generally estimated as a population average effect, despite drug responses varying among individuals according to a variety of measurable and non-measurable factors. Model-based and/or individual-level analyses are scarce and often methodologically frail. We propose that wider application of marginal and mixed models would offer benefits to the evaluation of ADE. We demonstrate, with a worked example, how model-based analyses: (i) capture the effects of correlation among hierarchically structured longitudinal data on estimates of ADE; (ii) permit robust inference on the association of measurable factors with ADE; and (iii) enable estimation of variation among individual-level estimates of ADE. The application of modelling approaches is discussed in the context of mass drug administration-based control of human helminthiases.

Keywords: albendazole; hookworm; longitudinal data; marginal models; mass drug administration; mixed models.

Publication types

  • Review

MeSH terms

  • Animals
  • Anthelmintics / therapeutic use*
  • Helminthiasis / drug therapy*
  • Humans
  • Linear Models
  • Models, Theoretical*

Substances

  • Anthelmintics