A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Nat Genet. 2014 Oct;46(10):1103-9. doi: 10.1038/ng.3094. Epub 2014 Sep 14.

Abstract

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

Publication types

  • Meta-Analysis

MeSH terms

  • Genetic Loci / genetics*
  • Genetic Predisposition to Disease / genetics*
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Polymorphism, Single Nucleotide*
  • Prostatic Neoplasms / genetics*
  • Risk Assessment
  • Risk Factors

Associated data

  • GEO/GSE27823
  • GEO/GSE28219
  • GEO/GSE28264
  • GEO/GSE29692
  • GEO/GSE32970
  • GEO/GSE33213
  • GEO/GSE51621

Grants and funding