Transcription activation by the adenovirus E1a protein

Nature. 1989 Mar 2;338(6210):39-44. doi: 10.1038/338039a0.


The adenovirus E1a protein stimulates transcription of a wide variety of viral and cellular genes. It is shown here that E1a has the two functions characteristic of a typical cellular activator: one direct E1a to the promoter, perhaps by interacting with a DNA-bound protein, and the other, an activating region, enables the bound activator to stimulate transcription.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoviridae / genetics*
  • Adenovirus Early Proteins
  • Cell Transformation, Viral
  • DNA-Binding Proteins / physiology*
  • Gene Expression Regulation*
  • Genes, Viral*
  • Models, Genetic
  • Oncogene Proteins, Viral / physiology*
  • Promoter Regions, Genetic
  • Transcription, Genetic*


  • Adenovirus Early Proteins
  • DNA-Binding Proteins
  • Oncogene Proteins, Viral